Generic Name: Tetrabenazine

  • What is Xenazine?

    Xenazine is used to treat chorea (involuntary movement of the limbs or facial muscles) associated with Huntington's disease.
  • What is the most important information I should know about Xenazine?

    Xenazine can increase the risk of depression and suicidal thoughts and behavior in patients with Huntington 's disease. Anyone considering the use of Xenazine must balance the risks of depression and suicidality with the clinical need for control of choreiform movements. Close observation of patients for emergence or worsening of depression, suicidality, or unusual changes in behavior should accompany therapy.
  • Who should not take Xenazine?

    Do not take Xenazine if you are allergic to any of its ingredients or if you have impaired liver function.
  • What should I tell my doctor before I take the first dose of Xenazine?

    Before you start Xenazine, tell your doctor about all prescription, over-the-counter, and herbal medications you are taking. Also talk to your doctor about your complete medical history, especially about emotional and mental health conditions (sadness, depression, thoughts of suicide, suicide attempts, anxiety, anger, agitation) or physical conditions such as liver problems, history of breast cancer, irregular heartbeat, or if you are pregnant, plan to become pregnant or are breastfeeding.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The initial starting dose of Xenazine is 12.5 milligrams (mg) every morning for the first week. The second week, your dose will increase to 25 mg, split into 2 doses. If your daily dose is increased to 37.5 or 50 mg, you will need to take Xenazine 3 times a day.

    If your doctor thinks you need to take more than 50 mg of Xenazine each day, you will need a blood test to see if that dose is safe for you. For most patients, the maximum recommended daily dose is 50-100 mg.

  • How should I take Xenazine?

    Take Xenazine exactly as directed by your doctor. Never take more or less Xenazine than your doctor has prescribed for you. Take Xenazine at the correct time each day.
  • What should I avoid while taking Xenazine?

    Do not drive a car or operate dangerous machinery until you know how Xenazine affects you.
  • What are possible food and drug interactions associated with Xenazine?

    If Xenazine is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Xenazine with alcohol or other sedatives, or neuroleptic drugs.
  • What are the possible side effects of Xenazine?

    The most serious side effect is depression and thoughts of suicide, tell your doctor at once if you become depressed or have thoughts about suicide while taking Xenazine.

    Side effects may include: parkinsonism, restlessness, trouble swallowing, irregular heartbeat, dizziness, fatigue, agitation, nausea

  • Can I receive Xenazine if I am pregnant or breastfeeding?

    There are no adequate and well-controlled studies in pregnant women. Xenazine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Xenazine passes into breast milk.
  • What should I do if I miss a dose of Xenazine?

    If you miss a dose of Xenazine, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
  • How should I store Xenazine?

    Store at room temperature.