Generic Name: Denosumab

  • What is Xgeva?

    Xgeva is a medicine used to prevent bone-related events in patients with bone metastases (spread of tumor from one organ to another) from certain types of tumors.

  • What is the most important information I should know about Xgeva?

    Xgeva can cause severe hypocalcemia (low blood calcium), which may present as tingling or muscle stiffness, twitching, spasms, or cramps. Contact your doctor if you experience any of these symptoms. Your doctor may require you to take calcium and vitamin D supplements to treat or prevent hypocalcemia.

    Xgeva can also cause osteonecrosis (jaw-bone problems), which may present as pain, numbness, or swelling of the jaw, mouth, or teeth. Contact you doctor or dentist if you experience any of these symptoms. Also, persistent pain or slow healing of the mouth or jaw may occur after dental surgery.

  • Who should not take Xgeva?

    Do not take Xgeva if your blood calcium is too low, you have a condition called multiple myeloma (a form of cancer), or if you are allergic to any of the ingredients in Xgeva.

  • What should I tell my doctor before I take the first dose of Xgeva?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Xgeva. Also, talk to your doctor about your complete medical history, especially if you have a history of kidney disease, have or had low blood calcium, are not able to take daily calcium and vitamin D supplements, have a planned dental procedure such as tooth removal, are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The recommended dose is 120 milligrams (mg) given as a subcutaneous (just below the skin) injection every 4 weeks in the upper arm, upper thigh, or abdomen (stomach area).

  • How should I take Xgeva?

    Your doctor will administer Xgeva.

  • What should I avoid while taking Xgeva?

    You should not receive Xgeva if you are already receiving Prolia. Xgeva and Prolia contain the same medication.

  • What are possible food and drug interactions associated with Xgeva?

    No significant interactions have been reported with Xgeva at this time. However, always tell your doctor about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

  • What are the possible side effects of Xgeva?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: dyspnea (shortness of breath), fatigue or asthenia (lack of strength), hypocalcemia, hypophosphatemia (low blood phosphate), nausea, osteonecrosis

  • Can I receive Xgeva if I am pregnant or breastfeeding?

    The effects of Xgeva during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Xgeva?

    Contact your doctor if you miss your scheduled appointment to receive Xgeva.

  • How should I store Xgeva?

    Your doctor will store and prepare this medication for you before you receive your dose.