Generic Name: Metolazone

  • What is Zaroxolyn?

    Zaroxolyn is used to treat fluid retention due to congestive heart failure, kidney problems, or nephrotic syndrome (kidney disorder in which too much protein is excreted into the urine). Zaroxolyn helps you form urine and get rid of excess body water.

    Zaroxolyn is also used to treat high blood pressure; it may be used alone or in combination with other drugs that treat high blood pressure.

  • What is the most important information I should know about Zaroxolyn?

    Allergic reactions to Zaroxolyn can occur with the first dose. Seek medical attention immediately if you have trouble breathing, swelling of the throat or face, or any other allergic-type reaction after taking Zaroxolyn. You may be more likely to experience an allergy to Zaroxolyn if you are also allergic to sulfonamide-type medicines, thiazide-type diuretics (water pills), or quinethazone.

    Use Zaroxolyn with caution if you are also currently taking other medicines to lower your blood pressure. Let your doctor know if you feel dizzy or lightheaded when you take Zaroxolyn.

    Zaroxolyn, especially when combined with alcohol, may cause dizziness, lightheadedness, or fainting. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

    Zaroxolyn may increase your blood sugar, and this may be especially of concern if you have diabetes.

    Zaroxolyn may cause changes in the levels of different electrolytes in the body, such as potassium and sodium. Your doctor will monitor your electrolytes. Warning signs of electrolyte imbalance may include dry mouth, thirst, weakness, drowsiness, muscle pains or cramps, rapid heart rate, nausea, and vomiting. Notify your doctor immediately if you experience any of these signs.

  • Who should not take Zaroxolyn?

    You should not take Zaroxolyn if you do not produce urine, or if you are allergic or sensitive to Zaroxolyn or any of its ingredients.

  • What should I tell my doctor before I take the first dose of Zaroxolyn?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zaroxolyn. Also, talk to your doctor about your complete medical history, especially if you have a history of kidney or liver problems, arrhythmias, diabetes, gout, lupus (disease that affects the immune system), blood disorders, or electrolyte abnormalities in your blood.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    The effective dosage of Zaroxolyn should be individualized according to what the medicine is being used for, as well as your response. A single daily dose is recommended.

    Fluid Retention due to Heart Failure or Kidney Disease

    Adults: The usual dose is 5-20 milligrams (mg) taken once a day.

    High Blood Pressure

    Adults: The usual dose is 2.5-5 mg once a day.

  • How should I take Zaroxolyn?

    Zaroxolyn should be taken exactly as prescribed by your doctor.

  • What should I avoid while taking Zaroxolyn?

    Do not stand or sit up quickly when taking Zaroxolyn, especially in the morning. Sit or lie down at the first sign of dizziness or lightheadedness.

  • What are possible food and drug interactions associated with Zaroxolyn?

    If Zaroxolyn is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zaroxolyn with the following: alcohol, blood thinners, barbiturates, corticosteroids or ACTH, muscle relaxants such as tubocurarine, digitalis glycosides, diuretics (especially furosemide or other loop-type diuretics), insulin and oral antidiabetic agents, lithium, medications that lower your blood pressure such as enalapril, methenamine, narcotics, norepinephrine, potassium, pain relievers such as aspirin and ibuprofen, and vitamin D.

  • What are the possible side effects of Zaroxolyn?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: chest pain, low blood pressure, fainting, dizziness, severe skin rash with peeling skin, tingling sensation, depression, yellowing of the skin or eyes, vomiting, nausea, diarrhea, constipation, loss of appetite, stomach pain or bloating, sore throat with fever, electrolyte abnormalities in the blood, joint pain, temporary blurred vision, chills

  • Can I receive Zaroxolyn if I am pregnant or breastfeeding?

    The effects of Zaroxolyn during pregnancy are unknown. Zaroxolyn is excreted in breast milk. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Zaroxolyn?

    If you miss a dose of Zaroxolyn, take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Zaroxolyn?

    Store at room temperature.

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