Ziac

Generic Name: Hydrochlorothiazide

  • What is this medication and its most common uses?

    Ziac is a medicine used to treat high blood pressure. Ziac contains two medicines that work in two different ways to reduce your blood pressure: bisoprolol and hydrochlorothiazide.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Bisoprolol works by decreasing your heart rate, and relaxing and widening your blood vessels, allowing your blood to flow through with less resistance. Hydrochlorothiazide is a water pill and works by eliminating extra fluid and sodium (salt) from your body. Together, they help to lower your blood pressure.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: By lowering your blood pressure, Ziac may lower your risk of a stroke or a heart attack.

    When: Ziac may start lowering your blood pressure within 1 week. Though you may not feel an improvement or change in the way you feel, it is very important to keep taking your medicine as prescribed to keep your condition under control.

    How do I know it is working?

    Check your blood pressure regularly. Your healthcare provider will also check your blood pressure at every visit. Following an appropriate diet and exercise plan will also affect your blood pressure results.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    More common side effects may include: dizziness, diarrhea.

    Less common side effects may include:

    Changes in electrolytes (chemicals that are important for the cells in your body to function, such as sodium and potassium) with symptoms such as dry mouth, thirst, weakness, tiredness, drowsiness, restlessness, muscle pains or cramps, muscle tiredness, dizziness or fainting, low or no urine output, fast heartbeat, or nausea and vomiting.

    Breathing problems or worsened heart failure with symptoms such as weight gain, increased shortness of breath, or a slow heartbeat.

    Ziac may hide symptoms of low blood sugar levels if you have diabetes.

    Temporary nearsightedness (trouble seeing objects farther away) or glaucoma (high pressure in the eye) with symptoms such as changes in your vision or eye pain that may occur within hours to weeks of starting Ziac.

  • Who should not take this medication?

    Do not take Ziac if you are allergic to it, any of its ingredients, or other sulfonamide medications (such as sulfamethoxazole).

    Do not take Ziac if you have certain heart problems (such as heart failure, a slow heartbeat, or your heart skips a beat).

    Do not take Ziac if you are unable to produce urine.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Ziac. Also, talk to your healthcare provider about your complete medical history, especially if you have lung problems (such as bronchitis or emphysema); problems with blood flow in your feet and legs; diabetes; lupus (a disease that affects the immune system); liver, kidney, or thyroid problems; or if you are scheduled for surgery.

    Tell your healthcare provider if you have a history of severe allergic reactions to any allergens, because Ziac may decrease the effectiveness of epinephrine, a medicine used to treat such reactions.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Adults: The usual starting dose is 2.5/6.25 (2.5 milligrams [mg] of bisoprolol and 6.25 mg of hydrochlorothiazide) once a day. Your healthcare provider may increase your dose as needed until the desired effect is achieved.

    If you have liver or kidney impairment, your healthcare provider may adjust your dose appropriately.

    It is important that you do not stop taking this medication abruptly. If you need to change or stop taking this medication, it is important that you only do this with the guidance of your healthcare provider.

  • How should I take this medication?

    Take Ziac exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Ziac without first talking to your healthcare provider.

  • What should I avoid while taking this medication?

    Do not drive a car, operate machinery, or engage in other tasks requiring alertness until you know how Ziac affects you.

  • What are the possible food and drug interactions associated with this medication?

    If Ziac is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Ziac with the following: alcohol, barbiturates (such as phenobarbital), blood pressure/heart medications known as calcium channel blockers (such as diltiazem or verapamil), cholestyramine, clonidine, colestipol, diabetes medicines (such as insulin), digoxin, disopyramide, guanethidine, lithium, muscle relaxants (such as tubocurarine), narcotic painkillers (such as morphine or oxycodone), nonsteroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen or naproxen), norepinephrine, reserpine, rifampin, or steroids (such as prednisone).

  • May I receive this medication if I am pregnant or breastfeeding?

    The effects of Ziac during pregnancy are unknown. Ziac can be found in your breast milk if you take it while breastfeeding. Do not breastfeed while you are taking Ziac. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of Ziac, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature.

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