Generic Name: Ondansetron

  • What is Zofran?

    Zofran helps prevent nausea or vomiting in patients who are receiving chemotherapy or radiation. Zofran is also used to prevent nausea or vomiting after surgery.

  • What is the most important information I should know about Zofran?

    Taking Zofran after you have had abdominal surgery, or to prevent nausea or vomiting from chemotherapy, may hide the signs and symptoms of stomach distension (bloating) or a disorder of the intestines known as progressive ileus (obstruction of the intestines).

    This drug may cause irregular heartbeats or rhythms, especially if you are receiving it by injection.

    If you have phenylketonuria (an inability to process phenylalanine, a protein in your body), it is important to know that Zofran ODT (orally disintegrating tablets) contains phenylalanine.

  • Who should not take Zofran?

    Do not take Zofran if you are taking apomorphine. Do not take Zofran if you are allergic to it or sensitive to any of its ingredients, or any other similar medication known as a 5HT-3 antagonist.

  • What should I tell my doctor before I take the first dose of Zofran?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zofran. Also, talk to your doctor about your complete medical history, especially if you have stomach, intestinal, or liver problems, or if you have phenylketonuria.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Nausea and Vomiting (Prevention and Postoperative)

    Your doctor will prescribe the appropriate dose for you.

  • How should I take Zofran?

    Zofran must be taken exactly as prescribed, with or without food.

    Your doctor will administer Zofran injection.

    Zofran ODT should not be pushed through the foil wrapping. With dry hands, carefully peel back the foil and place the tablet on the tip of the tongue, where it will dissolve, then swallow. Do not remove the foil packaging until it is time to take the medication.

  • What should I avoid while taking Zofran?

    Do not take more Zofran than prescribed unless directed by your doctor.

  • What are possible food and drug interactions associated with Zofran?

    If Zofran is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zofran with the following: apomorphine, carbamazepine, phenytoin, rifampicin, or tramadol.

  • What are the possible side effects of Zofran?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: constipation, diarrhea, drowsiness, dizziness, fatigue, headache, impaired wound healing, itching, decreased heart rate, fever, anxiety/agitation

  • Can I receive Zofran if I am pregnant or breastfeeding?

    The effects of Zofran during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Zofran?

    Zofran should be given under special circumstances determined by your doctor. If you miss your scheduled dose, it is best to speak to your doctor for advice.

  • How should I store Zofran?

    Store oral solution, ODT, and tablets at room temperature and protect from light. Your doctor will store Zofran Injection.

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