Generic Name: Piperacillin

  • What is Zosyn?

    Zosyn is an antibacterial agent (in the form of an injection) used to treat a wide variety of bacterial infections, including skin infections, pneumonia, and other moderate to severe types of infections.

  • What is the most important information I should know about Zosyn?

    If you are allergic to either penicillin or cephalosporin antibiotics in any form, consult your doctor before taking Zosyn. There is a possibility that you are allergic to both types of medications, and if a reaction occurs, it could be extremely severe. If you take the drug and notice any signs of a reaction, such as a skin rash, chills, fever, or swelling, seek medical attention immediately.

    A gastrointestinal condition has been reported with use of Zosyn and may range in severity from mild diarrhea to a severe inflammation of the large intestine. Patients may develop watery and bloody stools even as late as 2 or more months after having taken the last dose of the antibiotic. If this condition is suspected, Zosyn may need to be discontinued and appropriate therapy must be initiated.

    Zosyn should only be used to treat bacterial infections. It will not treat viral infections like the common cold.

    Although it is common to feel better early in the course of therapy, you should use this medication exactly as directed by your physician for the entire length of time prescribed. Complete the full course of therapy and do not skip any doses.

  • Who should not take Zosyn?

    Do not use Zosyn if you have a history of allergic reactions to any penicillins, cephalosporins, or beta-lactamase inhibitors.

  • What should I tell my doctor before I take the first dose of Zosyn?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zosyn. Also talk to your doctor about your complete medical history, especially if have cystic fibrosis, kidney disease or if you are on dialysis, a bleeding or clotting disorder, an electrolyte imbalance (such as low levels of potassium in your blood), or if you are on a salt-restricted diet.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: Zosyn is given as an intravenous infusion over the course of 30 minutes, usually every 6 hours. Your doctor will prescribe the appropriate dosage for you.

    Children 2 months and older: Your doctor will prescribe the appropriate dosage based on your child's condition, age, and weight.

  • How should I take Zosyn?

    Your doctor, nurse, or other healthcare provider will give you this injection. Take this medication for the entire length of time prescribed by your doctor. Skipping doses or not completing the full course of therapy may decrease the drug's effectiveness, increase the chances for bacterial resistance, and will not be treatable by Zosyn or other antibacterial drugs in the future.

  • What should I avoid while taking Zosyn?

    Avoid skipping doses or not completing the full course of therapy. Do not use any medicine to stop diarrhea without your doctor's approval.

  • What are possible food and drug interactions associated with Zosyn?

    If Zosyn is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zosyn with the following: a group of antibacterial drugs called aminoglycosides, heparin, methotrexate, oral anticoagulants or other drugs that may affect blood clotting, probenecid, and vecuronium.

  • What are the possible side effects of Zosyn?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: diarrhea, constipation, nausea, fever, vomiting, urinary tract infection, rash

  • Can I receive Zosyn if I am pregnant or breastfeeding?

    Zosyn should be used during pregnancy only when clearly needed. If you are pregnant or plan to become pregnant, inform your doctor immediately. Since Zosyn may appear in breast milk, you should consult your doctor if you plan to breastfeed your baby.

  • What should I do if I miss a dose of Zosyn?

    Zosyn should be given under special circumstances determined by your doctor. If you miss your scheduled dose, it is best to speak to your healthcare provider for advice.

  • How should I store Zosyn?

    Your physician will store this medication.

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