Generic Name: Ondansetron

  • What is Zuplenz?

    Zuplenz is used in adults to prevent nausea and vomiting caused by certain cancer chemotherapy medicines, radiation therapy to the stomach or the entire body, or vomiting that may happen after surgery.

    In children ≥4 years, Zuplenz is only used to prevent nausea and vomiting due to certain cancer chemotherapy medicines.

  • What is the most important information I should know about Zuplenz?

    Zuplenz may cause serious side effects, including severe allergic reactions and heart rhythm changes.

    Stop taking Zuplenz and tell your doctor right away if you have any signs or symptoms of an allergic reaction (such as rash, hives, itching, trouble breathing, chest tightness or chest pain, swelling of your mouth, face, lips, or tongue).

  • Who should not take Zuplenz?

    Do not take Zuplenz if you take apomorphine hydrochloride (Apokyn). Do not take Zuplenz if you have had an allergic reaction to ondansetron or any of its other ingredients.

  • What should I tell my doctor before I take the first dose of Zuplenz?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zuplenz. Also, talk to your doctor about your complete medical history, especially if you have liver problems, any other medical conditions, are pregnant or plan to become pregnant, are breastfeeding, or have had an allergic reaction to another medicine for nausea and vomiting.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Nausea and Vomiting from Highly Vomit-Inducing Chemotherapy

    Adults: The recommended dose is 24 milligrams (mg) given as three 8-mg films taken 30 minutes before the start of chemotherapy.

    Nausea and Vomiting from Moderate Vomit-Inducing Chemotherapy

    Adults and children >12 years: The recommended dose is one 8-mg film taken twice a day. Take the first dose 30 minutes before the start of chemotherapy. Take the second dose 8 hours later. One 8-mg film should be taken every 12 hours for 1-2 days after completing chemotherapy.

    Children 4-11 years: The recommended dose is one 4-mg film taken three times a day. Take the first dose 30 minutes before chemotherapy, with the following doses 4 and 8 hours after the first dose. One 4-mg film should be taken three times a day (every 8 hours) for 1-2 days after completing chemotherapy.

    Nausea and Vomiting from Radiation

    Adults: The recommended dose is one 8-mg film taken three times a day.

    For total body radiation and radiation to your abdomen, your doctor will prescribe the appropriate dose for you.

    Nausea and Vomiting after an Operation

    Adults: The recommended dose is 16 mg given as two 8-mg films 1 hour before anesthesia.

  • How should I take Zuplenz?

    Take Zuplenz only as directed by your doctor. An adult should help a young child use this medicine.

    Use the film strip right away, after you remove it from the pouch. Make sure your hands are dry. Fold the pouch along the dotted line to expose the tear notch. While still folded, tear the pouch carefully along the edge. Take the film strip from the pouch. Put the Zuplenz film on top of your tongue, where it will dissolve in 4-20 seconds. Swallow after the film dissolves. You may swallow the dissolved film with or without liquid. Wash your hands after taking Zuplenz.

  • What should I avoid while taking Zuplenz?

    Do not chew or swallow the film whole.

  • What are possible food and drug interactions associated with Zuplenz?

    If Zuplenz is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zuplenz with the following: apomorphine, carbamazepine, phenytoin, and rifampicin.

  • What are the possible side effects of Zuplenz?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: severe allergic reactions (such as rash, chest tightness or chest pain, hives, itching, swelling of the mouth, face, lips, or tongue), trouble breathing, heart rhythm changes, headache, tiredness and body discomfort, constipation, diarrhea

  • Can I receive Zuplenz if I am pregnant or breastfeeding?

    The effects of Zuplenz during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Zuplenz?

    If you miss a dose of Zuplenz, take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Zuplenz?

    Store at room temperature. Keep the film in the foil pouch until ready to use. Keep foil pouches in the carton.

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