Generic Name: Bupropion hydrochloride (for smoking cessation)

  • What is Zyban?

    Zyban is a nicotine-free medication used to help people quit smoking.
  • What is the most important information I should know about Zyban?

    About 1 person in 1,000 suffers a seizure while taking Zyban. For this reason, people with epilepsy should never take this medication. Do not share Zyban with your friends. Only a doctor can decide whether it's safe for a particular individual to take this medication.

    Zyban contains the same ingredient as the antidepressants Wellbutrin, Wellbutrin SR, and Wellbutrin XL. Antidepressants can increase the risk of suicidal thinking and behavior in children and teenagers. Adult and pediatric patients taking antidepressants should be watched closely for changes in moods or actions, especially when they first start therapy or when their dose is increased or decreased. Patients and their families should contact the doctor immediately if new symptoms develop or seem to get worse. Signs to watch for include anxiety, hostility, sleeplessness, restlessness, impulsive or dangerous behavior, and thoughts about suicide or dying.

  • Who should not take Zyban?

    Do not take Zyban if you have a seizure disorder, anorexia or bulimia (eating disorders), or if you are going through alcohol recovery. In addition, you should not take Zyban if you are taking any other medicines that contain bupropion hydrochloride, such as Wellbutrin, Wellbutrin SR, or Wellbutrin XL, or if you have suddenly stopped taking sedatives.

    Do not take monoamine oxidase inhibitors (MAOIs) within 2 weeks before or after treatment with this medication. In some cases a serious, possibly fatal, reaction may occur. Examples of MAOIs include selegiline and the antidepressants phenelzine and tranylcypromine.

    Also, do not begin treatment with Zyban if you are allergic to any of its ingredients.

  • What should I tell my doctor before I take the first dose of Zyban?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zyban. Also, talk to your doctor about your complete medical history, especially if you have ever had a seizure, eating disorders, liver or kidney problems, heart problems, high blood sugar, head injuries, or an addiction (e.g., alcohol or drug abuse).
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The recommended starting dose is 150 milligrams (mg) a day for the first 3 days. If needed, the doctor may increase your dose up to a maximum dose of 300 mg a day, given in two divided doses.

  • How should I take Zyban?

    Take Zyban exactly as prescribed by your doctor. Swallow the tablets whole; do not chew, divide, or crush them. Take the tablets at the same time each day, at least 8 hours apart.
  • What should I avoid while taking Zyban?

    Do not drink alcohol or smoke while taking Zyban. If you currently drink a lot of alcohol and suddenly stop, you should tell your doctor, since this may increase your risk of having a seizure. You should also not drive a car or operate heavy machinery until you know how this drug affects you.
  • What are possible food and drug interactions associated with Zyban?

    If Zyban is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zyban with any the following: alcohol, amantadine, antidepressants, blood pressure medications called beta-blockers, carbamazepine, cimetidine, cyclophosphamide, heart-stabilizing drugs, levodopa, major tranquilizers, MAOIs, orphenadrine, phenobarbital, phenytoin, steroids such as prednisone and hydrocortisone, theophylline, and warfarin.
  • What are the possible side effects of Zyban?

    Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects include: dry mouth, difficulty sleeping

  • Can I receive Zyban if I am pregnant or breastfeeding?

    Zyban has not been tested in pregnant women. If you are pregnant or plan to become pregnant, do your best to quit smoking with the aid of counseling and support before taking Zyban. You should avoid smoking or taking nicotine in any other form while pregnant.

    Zyban appears in breast milk and could affect a nursing infant. Ask your doctor whether it will be better to discontinue the medication or to stop breastfeeding.

  • What should I do if I miss a dose of Zyban?

    Do not double your next dose. Skip the dose you missed and return to your regular dosing schedule. This is very important because taking too much Zyban can increase your risk of having a seizure.
  • How should I store Zyban?

    Store at room temperature away from light and moisture.