Generic Name: Allopurinol

  • What is this medication and its most common uses?

    Zyloprim is a medicine used to treat gout, high levels of uric acid in the body caused by certain cancer medications, and kidney stones.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    High levels of uric acid may cause gout attacks or kidney stones. Zyloprim works by reducing the production of uric acid in your body.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: By reducing the amount of uric acid in your body, Zyloprim may help relieve your symptoms of gout.

    When: Zyloprim may start decreasing uric acid levels in your body within 1 week of taking it.

    How do I know it is working?

    Your healthcare provider may ask you a series of questions from time to time that will help assess how well your symptoms are controlled with treatment, and may perform tests to check the uric acid levels in your body.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    More common side effects may include: skin rash.

    Less common side effects may include:

    Liver problems with symptoms such as weight loss, loss of appetite, or itching.

    Zyloprim may cause drowsiness, or an increase in sudden gout attacks (especially during the early treatment stages).

  • Who should not take this medication?

    Do not take Zyloprim if you are allergic to it or any of its ingredients.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zyloprim. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney or liver problems.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.


    Adults: The recommended starting dose is 100 milligrams (mg) a day.

    Recurrent Kidney Stones

    Adults: The recommended dose is 200 to 300 mg a day in divided doses or as a single dose, as directed by your healthcare provider.

    Increased Uric Acid Due to Cancer Treatment

    Adults and children: Your healthcare provider will prescribe the appropriate dose for you or your child, and may adjust the dose as needed.

    If you have kidney impairment, your healthcare provider may adjust your dose appropriately.

  • How should I take this medication?

    Take Zyloprim exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Zyloprim without first talking to your healthcare provider.

    Take Zyloprim after meals to reduce stomach irritation.

    Drink plenty of fluids while you are taking Zyloprim.

  • What should I avoid while taking this medication?

    Do not drive, operate heavy machinery, or do other dangerous activities until you know how Zyloprim affects you.

  • What are the possible food and drug interactions associated with this medication?

    If Zyloprim is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Zyloprim with the following: amoxicillin, ampicillin, azathioprine, certain water pills (such as hydrochlorothiazide), chlorpropamide, cyclosporine, mercaptopurine, or sulfinpyrazone.

  • May I receive this medication if I am pregnant or breastfeeding?

    The effects of Zyloprim during pregnancy are unknown. Zyloprim can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of Zyloprim, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature in a dry place. Protect from light.

Meet the Pharmacists

I'm Beth Isaac, PharmD. Welcome to PDR Health!

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