Zyprexa Relprevv

Generic Name: Olanzapine

  • What is Zyprexa Relprevv?

    Zyprexa Relprevv is a long-acting drug known as an "atypical antipsychotic." It is given by injection for the treatment of schizophrenia in adults.

  • What is the most important information I should know about Zyprexa Relprevv?

    To receive Zyprexa Relprevv, you have to talk to your doctor to understand the benefits and risks of Zyprexa Relprevv. You must also and register for and agree to the rules of the Zyprexa Relprevv Patient Care Program.

    Serious side effects may happen when you take Zyprexa Relprevv, including post-injection delirium sedation syndrome (PDSS), a serious reaction that can happen if the medicine gets in your blood too fast. If this happens, you may experience any of the following: excessive sleepiness, dizziness, confusion or disorientation, trouble talking or walking, stiff or twitching muscles, weakness, feel angry or irritable, nervousness or anxiety, higher blood pressure, seizures, or loss of consciousness (including coma). If you have symptoms of PDSS, you need to get medical help or be taken to an emergency room right away.

    Medicines like Zyprexa Relprevv can raise the risk of stroke or death in elderly people who have memory loss (dementia). Zyprexa Relprevv is not approved for treating psychosis in the elderly with dementia.

    Zyprexa Relprevv and similar medications have been associated with an increased risk of developing high blood sugar, which on rare occasions has led to coma or death. See your doctor right away if you develop signs of high blood sugar, including dry mouth, unusual thirst, increased urination, and fatigue.

    Zyprexa Relprevv can cause weight gain and high cholesterol and triglyceride levels. You should monitor your weight and have blood tests to check your cholesterol and triglyceride levels throughout treatment.

    Zyprexa Relprevv may cause tardive dyskinesia, a potentially irreversible condition that causes involuntary muscle spasms and twitches in the face and body. Elderly women appear to be at a higher risk for this condition. Notify your doctor immediately if you experience any involuntary muscle movements.

    Zyprexa Relprevv may cause neuroleptic malignant syndrome (NMS), a potentially fatal condition marked by muscle stiffness or rigidity, fast heartbeat or irregular pulse, increased sweating, high fever, and blood pressure irregularities. Call your doctor immediately if you notice any of these symptoms.

    Zyprexa Relprevv may affect the production of disease-fighting white blood cells. Call your doctor right away if you have any signs of a fever or infection.

    In rare instances, Zyprexa Relprevv has been shown to induce seizures. Caution should be used in patients with a history of seizures.

  • Who should not take Zyprexa Relprevv?

    Zyprexa Relprevv should not be used in elderly patients who have dementia due to an increased risk of death.

    Zyprexa Relprevv is not approved for use in people less than 18 years old. Possible serious risks of weight gain and increases in cholesterol and triglycerides are more common in teenagers than in adults.

    Avoid taking Zyprexa Relprevv if you are pregnant or breastfeeding.

  • What should I tell my doctor before I take the first dose of Zyprexa Relprevv?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zyprexa Relprevv. Also, talk to your doctor about your complete medical history, especially if you have liver or kidney disease, alcohol and tobacco use, high or low blood pressure, history of a heart attack or stroke, high cholesterol, seizures, diabetes or elevated blood sugar, Alzheimer's disease or dementia, history of suicidal thoughts, history of obesity, low white blood cell count, narrow-angle glaucoma, prostate problems, breast cancer, or bowel obstruction. In addition, tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Your doctor will prescribe the appropriate dosage for you.

  • How should I take Zyprexa Relprevv?

    Zyprexa Relprevv will be injected into the buttock muscle by your doctor or nurse at the clinic. You will need to stay at the clinic for at least 3 hours. When you leave the clinic, someone must be with you. You should not drive or use heavy machinery for the rest of the day after receiving Zyprexa Relprevv. Call your doctor if you do not think you are getting better or if you have any concerns about your condition while taking Zyprexa Relprevv.

  • What should I avoid while taking Zyprexa Relprevv?

    You should not drive, operate heavy machinery, or do other dangerous activities until you know how Zyprexa Relprevv affects you. Zyprexa Relprevv may make you sleepy and may affect your ability to make decisions, think clearly, or react quickly.

    Avoid drinking alcohol while taking Zyprexa Relprevv; this could make you sleepier than usual.

    Zyprexa Relprevv can raise body temperature. Avoid getting overheated or dehydrated. Do not over-exercise. In hot weather, stay inside in a cool place if possible. Stay out of the sun and drink plenty of water. Call your doctor right away if you become severely ill and or develop symptoms of dehydration (e.g., dizziness, headache, or dark-colored urine).

    When you first start taking Zyprexa Relprevv, you can develop very low blood pressure, increased heart rate, dizziness, and, in rare cases, a tendency to faint when first standing up. These problems are more likely to occur if you are dehydrated, have heart problems, or take blood pressure medications. When sitting or lying down, stand up slowly to avoid any feelings of lightheadedness or dizziness, especially in the morning. Sit or lie down at the first sign of any of these effects.

  • What are possible food and drug interactions associated with Zyprexa Relprevv?

    If Zyprexa Relprevv is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zyprexa Relprevv with the following: alcohol, carbamazepine, drugs that affect the central nervous system, diazepam, fluoxetine, fluvoxamine, high blood pressure medicines, levodopa and other dopamine agonists, lorazepam (given by injection into the muscle), omeprazole, and rifampin.

    Do not start or stop any medicine while taking Zyprexa Relprevv without talking to your doctor first.

  • What are the possible side effects of Zyprexa Relprevv?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: post-injection delirium sedation syndrome (PDSS), cerebrovascular events (e.g., stroke), neuroleptic malignant syndrome (stiff muscles, altered mental state), irregular pulse, irregular blood pressure, increase in heart rate, irregular heartbeat, seizures, involuntary movements, weight gain, increased appetite, high blood sugar and diabetes, low white blood cell count, dizziness upon standing, suicidal thoughts, impaired judgment, infections, headache, sleepiness or drowsiness, dry mouth, diarrhea, nausea, common cold, vomiting, cough, back pain, pain at the injection site

    Zyprexa Relprevv may increase the amount of a certain hormone (prolactin) in your blood. Contact your doctor right away if you experience enlarged breasts, missed menstrual period, decreased sexual ability, or nipple discharge.

  • Can I receive Zyprexa Relprevv if I am pregnant or breastfeeding?

    If you are pregnant or plan to become pregnant, inform your doctor immediately. Zyprexa Relprevv should be used during pregnancy only if absolutely necessary. Zyprexa Relprevv may appear in breast milk; do not breastfeed while taking this medication.

  • What should I do if I miss a dose of Zyprexa Relprevv?

    Zyprexa Relprevv should be given under special circumstances determined by your doctor. If you miss your scheduled dose, it is best to speak to your healthcare provider for advice.

  • How should I store Zyprexa Relprevv?

    You healthcare provider will store Zyprexa Relprevv.

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